Decentralized Science (DeSci) has emerged. This is a new concept in the world of Web3. The main goal of DeSci is to achieve fair and equitable funding, creation, review, storage, and dissemination of scientific knowledge through establishing public infrastructure and using Web3 tools (including NFTs, smart contracts, DAOs, etc.). Finally, the article points out that although DeSci offers a new research model, its development still faces many challenges, such as the quality of research projects and how to improve the governance system of DAOs, which can be solved based on further effort and innovation.